Pepto-Bismol Drug Interactions

by on May 3, 2012

Some prescription medications and over-the-counter products can negatively interact with Pepto-Bismol, causing potentially dangerous drug side effects. Talk to your doctor before using Pepto-Bismol if you take any of the following medications:

  • Diamox (acetazolamide)
  • Azopt (brinzolamide ophthalmic)
  • Bexxar Therapeutic (tositumomab)
  • Cosopt (dorzolamide/timolol ophthalmic)
  • Daranide (dichlorphenamide)
  • Sprycel (dasatinib)
  • Exjade (deferasirox)
  • Xigris (drotrecogin alfa)
  • FluMist (influenza virus vaccine, live, trivalent)
  • Folex PFS, Methotrexate LPF Sodium, Rheumatrex or Trexall (methotrexate)
  • Glauctabs, MZM or Neptazine (methazolamide)
  • Zevalin (ibritumomab)
  • Trusopt (dorzolamide ophthalmic)
  • Coumadin or Jantoven (warfarin)
  • Benemid (probenecid)
  • Doryx, Oracea, Periostat or Vibramycin (doxycycline)
  • Dynacin, Minocin or Solodyn (minocycline)
  • Ala-Tet, Brodspec, Panmycin, Sumycin or Tetracap (tetracycline)
  • Activase (alteplase)
  • TNKase (tenecteplase)
  • Insulin or oral diabetes medications
  • Salicylates such as aspirin, Trilisate, Nuprin Backache Caplet, Pamprin Cramp Formula, Kaopectate, Tricosal and KneeRelief

You should also tell your doctor about any vitamins, nutritional supplements or herbal products that you are currently taking, or planning to take, while using Pepto-Bismol. Although not regulated by the Food and Drug Administration, natural products may interact with prescription and over-the-counter medications.

Your doctor will be able to advise you on how to schedule doses of your various medications to avoid potentially serious Pepto-Bismol side effects or drug interactions.