Celebrex Dosage

Your healthcare provider determines the effective Celebrex dosage depending on a number of factors that include your age, the medical condition you are being treated for, the severity of the condition, and other underlying medical conditions.

The general rule is that patients be given the lowest effective dose and for the shortest duration. It must be consistent with the unique treatment goals for the patient.

Celebrex doses may be taken without regard to meals.

The following information provides the average Celebrex dosage, as prescribed by most physicians. If you get a different dosage, do not adjust or change it without consulting your healthcare provider. Take note that not all patients experience the same symptoms therefore it is possible for you to have a totally different dosage.

Management of Symptoms for Different Types of Arthritis

Osteoarthritis

• The recommended oral dose is 200 mg taken as a single dose or in two divided doses.

Rheumatoid Arthritis

• The recommended oral dose is 100 to 200 mg taken twice a day.

Juvenile Rheumatoid Arthritis

• Pediatric patients (2 years old and above) are given a Celebrex dose based on the child’s weight:
  • For children weighing more than 10 kg but less than 25 kg, the recommended oral dose is 50 mg taken in two divided doses.
  • For children weighing more than 25 kg, the recommended oral dose is 100 mg taken in two divided doses.
• Usually, pediatric patients have difficulty swallowing capsules. To facilitate swallowing, the contents of a Celebrex capsule can be mixed with applesauce. Make sure that the entire content of the capsule is carefully emptied and mixed onto the applesauce. Swallow the mixture immediately upon mixing then followed with water. If the medication mixture is not taken immediately, it must be stored in refrigerated condition. Kept in refrigerated condition, the mixture can remain stable for up to 6 hours.

Ankylosing Spondylitis

• The recommended oral dose is 200 mg taken as a single dose or in two divided doses. If the desired effect is not achieved after 6 weeks, the medication may be increased to 400 mg per day. If the desired effect is not achieved after 6 weeks on 400 mg per day, other alternative treatments must be considered.

Management of Acute Pain and Menstrual Pain

The recommended initial dose is 400 mg, followed by an additional 200 mg if necessary during the first day. Maintenance dose is usually 200 mg twice daily as needed.

Use in Special Populations

Patients with Liver Problems

• Patients with moderate hepatic insufficiency should be given half (50%) the lowest recommended dose. Meanwhile, the use of Celebrex in patients with severe liver problem is not recommended.

Poor Metabolizers of CYP2C9 Substrates

• Caution must be taken when using Celebrex in patients who are known or suspected to be poor CYP2C9 metabolizers based on genetics or previous experience with medications such as warfarin and phenytoin. As much as possible, consider using other treatment options. If Celebrex is necessary, start the treatment at half the recommended dose.