Estradiol Dosage

by on June 28, 2012

Estradiol is a female sex hormone produced by the ovaries. It has also been synthesized as a drug that is used for the treatment of conditions connected with absent or decreased production of endogenous estrogens. The recommended dose varies depending on the treated condition and the form of estradiol that is used – tablets, injectable solutions, patches, creams etc.

Adult dose for postmenopausal symptoms or after surgical removal of the ovaries:

Tablets – 0,5 to 2 mg estradiol once a day.

Injections – Estradiol valerat – single intramuscular dose of 10 mg. The dose is repeated every 2 - 6 weeks.

Estardiol cypionate -1,5 – 5 once a month IM

Transdermal theraupetic systems (TTS) – these are patches that are applied directly to the skin. This is a system that allows steady 24-hour percutaneous absorption of estradiol in very low doses (0,025 to 0,1mg a day). The rate of adverse effects is lower compared to the oral and injection formulations. One patch at a time is applied on the skin of the back or the abdomen. It should not be applied on the breast skin and on skin that is exposed to sunlight. After 7 days a new patch is applied at a different site from the previous one. Your doctor will probably start with the lowest possible dose and will increase it only if the effect is not sufficient. Usually the treatment is cyclic, i.e. after 3 weeks of treatment, there is a week pause. No pauses are made if the uterus of the woman has been removed or in the case of severe climacteric symptoms.

Vaginal rings – it is inserted in the vagina and usually stays there for 90 days releasing 2 mg of estradiol for the whole period.

Vaginal creams – 1% Estradiol. It should be applied 2-3 times a day on the mucosa and the skin in the cases of senile vaginal atrophy, pruritus or dryness.

Adult dose for amenorrhea, uterus hypoplasia or delayed sexual development:

Tablets – 1-2mg daily for 20 days followed by а 7 day pause. Your doctor may decide to combine estradiol with progesterone.

Injections - Estradiol valerat

Estradiol valerat is administered in a single dose of 20 mg for the treatment of amenorrhea. After 14 days a second dose of 10 mg combined with progesterone is recommended. The treatment lasts from 3 to 6 months.

Estardiol cypionate -1,5 – 2 once a month IM

Adult dose for the treatment of prostate cancer:

Tablets – 1-2 mg 3 times a day

Injections - Estradiol valerat – 30 mg IM once a week or at two weeks.

Estradiol is not used in children.

What to remember when using estradiol?

Estradiol is a prescription medicine and you should never use it without consulting a doctor.

An initial check-up before starting hormone replacement therapy is necessary as well as regular check-ups during the treatment.

Have in mind that sport can stimulate the endogenous secretion of estradiol and contribute to alleviating some menopausal symptoms and lowering of the needed dose of estradiol in hormone replacement therapy.

Take estradiol exactly the way it is prescribed by your doctor.