Lisinopril Drug Interactions

by on April 15, 2012

Lisinopril is often used in combination with other drugs to treat high blood pressure; ironically, however, it is also one of the drugs most likely to induce adverse reactions when combined with certain other medications.

For instance, if lisinopril is taken with diuretics, the patient is at increased risk of dangerously low blood pressure. Additionally, lithium may increase the chances of experiencing one or more of the common (or serious) adverse effects of lisinopril. Even NSAIDs such as Asprin pose a problem, as they may decrease the effectiveness of the drug.

The following is a list of medications which can produce severe interactions with Lisinopril.  The list is not complete and you should always consult with your doctor before starting a medication or combining medications.

  • NSAIDs such Asprin, Ibuprofen (Motrin, Advil) and Aleve
  • Insulin and Diabetes Medications such as Metformin and Lantus
  • Lithium
  • Allopurinol
  • Salt substitiues that contain potassium or any potassium supplements
  • Diuretics (Water pills)

Other common drugs are known to have a moderate to mild interaction with Lisnopril.  These interactions are usually manageable and in most cases can be remedied by adjusting the dosages or times of administration. These drugs may include, but are not limited to:

  • Abilify
  • Actiq
  • Ambien
  • Bactrim
  • Benadryl
  • Celebrex
  • Codeine
  • Meloxicam
  • Oxycontin (Oxycodone)
  • Percocet
  • Prednisone
  • Seroquel
  • Soma
  • Symbicort
  • Trazodone
  • Tylenol
  • Valium (Diazepam)
  • Wellbutrin
  • Xanax (Alprazolam)
  • Yasmin (Yaz)
  • Zyprexa
  • Zyrtec