Progesterone Dosage

Each patient is given a unique progesterone dosage. Be sure to read your prescription label carefully and take the medication exactly as prescribed by your healthcare provider. Below is the average dose for progesterone. If your healthcare provider prescribes a different dose, do not adjust your dose unless specifically instructed.

The progesterone dosage you take depends on a number of factors that include the strength and formulation of the medication, the frequency of dose, the time interval between each dose, and the duration of treatment.  The effective amount of medication prescribed for you depends on the medical condition being treated.

Oral Progesterone (Capsules)

Prevention of endometrial hyperplasia (thickening of the lining of the uterus) in postmenopausal women taking estrogen replacement therapy:

• 200 mg per day taken at bedtime for 12 continuous days during a 28-day cycle of estrogen treatment every month.

Treatment of amenorrhea (unusual cessation of menstrual periods):

• 400 mg per day at bedtime for 10 days.

Vaginal Progesterone (Gel)

Treatment of amenorrhea (unusual cessation of menstrual periods):

• 45 mg or one applicatorful of 4% gel every other day for a maximum of 6 doses. For some patients, dose may be increased to 90 mg or one applicatorful of 8% gel every other day for a maximum of six doses.

Use for certain infertility procedures:

• 90 mg or one applicatorful of 8% gel applied once or twice a day. In case of successful pregnancy, treatment may be extended for up to 10 to 12 twelve weeks.

Vaginal Progesterone (Suppository)

Maintaining a pregnancy (may be used at ovulation and at the start of pregnancy):

• 25 to 100 mg or 1 suppository inserted into the vagina 1 to 2 times a day starting near the time of ovulation. Usually, the treatment lasts for up to 11 weeks.

Injection Progesterone (Parenteral Solution)

Management of dysfunctional uterine bleeding (abnormal, heavy bleeding of the uterus) or treatment of amenorrhea

• 5 to 10 mg per day injected into a muscle for a period of six to ten days. Your healthcare provider may also choose to give you a single dose of 100 to 150 mg of progesterone. Usually, parenteral progesterone is given along with a different hormone called estrogen. The medication may be withheld at the start of the menstrual period.

Your healthcare provider may also prescribe progesterone for other medical conditions. The dosage depends on your condition and response to treatment. Progesterone is not normally prescribed to children.