Savella Drug Interactions

by on April 19, 2012

Savella, generic name Milnacipram Hydrochloride, is used to manage the pain associated with fibromyalgia. Though a very effective treatment, there are drug interactions that can have a negative effect on the outcome of treatment.

Patients who are taking certain other prescription drugs, such as Monoamine Oxidase Inhibitors (MAOIs), may have an increased risk for negative drug interactions.

Important to note is drug interactions that can affect the efficacy and safety of Savella treatment. There are some 400 drugs that can interact with this medication, making it very important to ensure the prescribing physician is aware of any medications you may be taking. Of urgent importance would be notifying your doctor is you take any medication such as the following: blood thinners, diuretics, clonidine, epinephrine, lithium, tramadol, and any medications used to treat psychiatric disorders including antidepressants. In general, when beginning any new drug it is important that you fully disclose any medications to your physician in order to avoid drug interactions that may be harmful.

Talk to your doctor about the medications that you are taking, specifically those mentioned below, before taking Savella.

  • Marplan (isocarboxazid)
  • Nardil (phenelzine)
  • Eldepryl, Emsam or Zelapar (selegiline)
  • Parnate (tranylcypromine)
  • Coumadin (warfarin)
  • Advil or Motrin (ibuprofen)
  • Aleve or Naprosyn (naproxen)
  • Catapres (clonidine)
  • Anafranil (clomipramine)
  • Lanoxicaps, Digitek or Lanoxin (digoxin)
  • Cymbalta (duloxetine)
  • Epipen or Primatene Mist (epinephrine)
  • Eskalith or Lithobid (lithium)
  • Axert (almotriptan)
  • Relpax (eletriptan)
  • Frova (frovatriptan)
  • Amerge (naratriptan)
  • Maxalt (rizatriptan)
  • Imitrex (sumatriptan)
  • Zomig (zolmitriptan)
  • Celexa (citalopram)
  • Lexapro (escitalopram)
  • Prozac or Sarafem (fluoxetine)
  • Luvox (fluvoxamine)
  • Paxil (paroxetine)
  • Zoloft (sertraline)
  • Effexor (venlafaxine)
  • Mellaril (thioridazine)
  • Azilect (rasagiline)

Savella and Monoamine Oxidase Inhibitors

Serious and potentially fatal side effects may occur if Savella is taken with a Monoamine Oxidase Inhibitor, or shortly after stopping an MAOI treatment regimen. To avoid serious or fatal side effects, wait at least 14 days between the end of an MAOI treatment and the beginning of a Savella treatment. If you quit taking Savella, you must wait at least five days before resuming MAOIs.