Grapefruit and Prescription Medications
Fruit is an essential part of a healthy diet. While it is recommended to eat a few servings of fruit each day, it is also important to note that certain fruits can interfere with the pharmacological action of certain medications. Some of these interactions may have minor side effects, but unfortunately, others may cause side effects, which can be life threatening, or even fatal.
The FDA has recently issued a reminder that Grapefruit is one fruit that has the ability to interact with many prescription medications and according to a study one in five Americans eat or drink Grapefruit every day for breakfast.
Grapefruit May Increase or Decrease Drug Potency
Depending on the type of medication, grapefruit has the ability to either weaken or strengthen its pharmacological action. In other words, it can either result in the drug not working at all or it can cause the drug to be too potent, which can lead to devastating side effects either way.
With some medications, the active compound in grapefruit juice (bergamottin) prevents the enzymes in the small intestine from doing their job, leading to a higher dose of the medication being absorbed by the body. This can lead to an overdose, which can be fatal.
Other medications are moved into the body’s cells by means of transporter proteins. Grapefruit has the ability to prevent these transporters from doing their job, which can then reduce the effectiveness of the medication.
Today, many pharmaceutical manufacturers state that their medications should not be taken with fruit juice. Because of these interactions, the FDA requires certain prescription medications to carry a warning about consuming grapefruit or grapefruit juice during use. It is important to note that these warnings also apply to certain non-prescription medications. That is why it is always recommended that the patient read the package insert that comes with the medication. If no mention is made about grapefruit or grapefruit juice, it is always best to consult with a doctor before consuming it during your treatment. Patients also need to ensure that other foods and juices they consume do not contain grapefruit or grapefruit juice while using certain medications.
Grapefruit Affects a Variety of Pharmaceuticals
Many pharmaceuticals are affected by grapefruit or grapefruit juice. Even consuming it a few hours before or after taking the drug can affect the absorption rate of many medications. Types of pharmaceuticals that are affected include:
- Organ transplant rejection medications like Neoral or Sandimmune
- Anti-arrhythmia medications like Cordarone, Carvedilol
- Antihistamines like Allegra, Claritin, Zyrtec
- Statin drugs such as Simvastatin, Lipitor and Lovastatin. Crestor, Livalo and Pravastatin (Pravachol) are not included.
- Blood pressure medications like Losartan and Afeditab
- Anti-anxiety and Anti-psychotic medications like BuSpar, Zoloft, Valium, Seroquel and Abilify
- Erectile Dysfunction Medications like Viagra (Sildenafil), Cialis (Tadalafil), and Levitra (Vardenafil).
- Potent pain relievers such as Codeine and Tramadol and Hydrocodone, and over the counter medications containing acetaminophen and paracetamol such as Tylenol
Because it is impossible to list every single pharmaceutical here which may be affected by grapefruit or grapefruit juice, it is important to consult with your doctor if you are unsure about any possible side-effects or interactions. For a more complete list you can visit this Wikipedia entry: http://en.wikipedia.org/wiki/Grapefruit_drug_interactions
Should You Stop Grapefruit Use?
If any of the drugs or medications you take are mentioned above then you should talk with your doctor to receive his or hers advice. If your medication is known to interact adversely with Grapefuit, then your doctor may present you with other options. In most cases, though it might be best to cut back on your consumption of grapefruit and grapefruit juice during the course of your treatment.
If your medication is not known to adversely interact with grapefruit and grapefruit juice then there’s no reason to stop its consumption, especially since grapefruit is an excellent source fo Vitamin C and can have a positive impact on your heart health.
I would like to know side effects on drug Jalyn
Grapes is good for the heart.But how much calorie does grapes had?
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